THE CONSORTIUM

Brought together by a need for change

It’s unacceptable that outcomes for children with brain cancer have seen little to no change in 40 years. Prior to the founding of PNOC, children with brain cancer were being treated with the same standard therapy as adults.

But children’s brains need specialized care.

To respond to this need, Dr. Michael Prados began exploring clinical strategies for children based on the molecular and genetic make-up of each child’s tumor. In order to move quickly towards implementation of highly innovative therapies, Dr. Prados struck out to establish the Pacific Pediatric Neuro-Oncology Consortium (PNOC).

Dr. Prados’ approach was disruptive, reflecting the Silicon Valley culture from his base at UC San Francisco. And it was working. Within a few years, PNOC, now co-led by Dr. Sabine Mueller, Dr. Cassie Kline and Dr. Michael Prados, has grown to become one of the U.S.’s most visible and prestigious pediatric brain cancer consortia, and PNOC currently has a waiting list of institutions eager to join.

In this position, PNOC is uniquely poised to make a significant difference for children, and has accomplished much in a short time. The collaborative nature of PNOC Consortium, the flexibility to develop trials based upon “real time” information, the freedom to conduct highly ambitious and high-reward studies, linking genomics to decisions, and samples to research strategies that we share among all interested parties, sets us apart.

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PNOC Participating Sites

Ann & Robert H. Lurie Children’s Hospital of Chicago, CHICAGO, IL

Children’s National Medical Center, WASHINGTON, DC

Duke University Medical Center, DURHAM, NC

Nationwide Children’s Hospital, COLUMBUS, OH

Princess Maxima Center, UTRECHT, THE NETHERLANDS

Riley Hospital for Children at Indiana University Health, INDIANAPOLIS, IN

St. Louis Children’s Hospital, ST. LOUIS, MO

Shaare Zedek Medical Center, ISRAEL

Sheba Medical Center, ISRAEL

The Children’s Hospital at Westmead, SYDNEY, AUSTRALIA

University of California, San Diego Rady Children’s Hospital, SAN DIEGO, CA

University of Florida Shands Children’s Hospital, GAINESVILLE, FL

Children’s Hospital of Michigan, DETROIT, MI

Children’s Hospital Los Angeles, LOS ANGELES, CA

Dana-Farber/Boston Children’s Cancer and Blood Disorders Center, BOSTON, MA

Johns Hopkins Hospital, BALTIMORE, MD

NYU Langone Health, NEW YORK CITY, NY

Queensland Children’s Hospital, BRISBANE, AUSTRALIA

Royal Children’s Hospital Melbourne, MELBOURNE, AUSTRALIA

Seattle Children’s Hospital, SEATTLE, WA

Sydney Children’s Hospital, RANDWICK, AUSTRALIA

Tata Memorial Centre, MUMBAI, INDIA

University Children’s Hospital Zürich, ZURICH, SWITZERLAND

UCSF Benioff Children’s Hospitals, SAN FRANCISCO, CA

University of Utah, SALT LAKE CITY, UT

Texas Children’s Hospital, HOUSTON, TEXAS

Children’s Minnesota, MINNEAPOLIS, MN

Doernbecher Children’s Hospital Oregon Health & Science University (OHSU), PORTLAND, OR

Joseph M. Sanzari Children’s Hospital at Hackensack University Medical Center, HACKENSACK, NJ

Perth Children’s Hospital, PERTH, AUSTRALIA

St. Jude Children’s Research Hospital, MEMPHIS, TN

St. Jude Children’s Research Hospital, MEMPHIS, TN

The Children’s Hospital of Philadelphia, PHILADELPHIA, PA

University of Alabama at Birmingham, Children’s of Alabama, BIRMINGHAM, ALABAMA

University of Michigan – C.S. Mott Children’s Hospital, ANN ARBOR, MI

Women’s and Children’s Hospital, ADELAIDE, AUSTRALIA

University of California, Los Angeles, LOS ANGELES, CA

University of California, Los Angeles, LOS ANGELES, CA

Yale University, Yale Cancer Center, NEW HAVEN, CT

"PNOC is uniquely poised to make a significant difference in children with CNS malignancies, and has accomplished much in a short time. The collaborative nature of our group, the flexibility to develop trials based upon 'real-time' information, the freedom to conduct high-risk and high-reward studies, linking genomics to decisions, and samples to research strategies that we share among all interested parties, sets us apart."

- Michael Prados, MD