THE CONSORTIUM

Brought together by a need for change

It’s unacceptable that outcomes for children with brain cancer have seen little to no change in 40 years. Prior to the founding of PNOC, children with brain cancer were being treated with the same standard therapy as adults.

But children’s brains need specialized care.

To respond to this need, Dr. Michael Prados began exploring clinical strategies for children based on the molecular and genetic make-up of each child’s tumor. In order to move quickly towards implementation of highly innovative therapies, Dr. Prados struck out to establish the Pacific Pediatric Neuro-Oncology Consortium.

Dr. Prados’ approach was disruptive, reflecting the Silicon Valley culture from his base at UC San Francisco. And it was working. Within a few years, PNOC, now led by Dr. Sabine Mueller and Dr. Michael Prados, has grown to become one of the U.S.’s most visible and prestigious pediatric brain cancer consortia, and PNOC currently has a waiting list of institutions eager to join.

In this position, PNOC is uniquely poised to make a significant difference for children, and has accomplished much in a short time. The collaborative nature of PNOC Consortium, the flexibility to develop trials based upon “real time” information, the freedom to conduct highly ambitious and high-reward studies, linking genomics to decisions, and samples to research strategies that we share among all interested parties, sets us apart.

Our Visionaries

Sabine Mueller, MD, PhD

Michael Prados, MD

PNOC MEMBERS

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Dana-Farber/Boston Children's Cancer and Blood Disorders Center

Children's Hospital Los Angeles

UCSF Benioff Children's Hospital of San Francisco and Oakland

University of California, San Diego Rady Children's Hospital

University of Utah

University of Florida Health Shands Children’s Hospital, Gainesville

Children's National Medical Center

Doernbecher Children’s Hospital Oregon Health & Science University (OHSU)

Ann & Robert H. Lurie Children’s Hospital of Chicago

The Children’s Hospital of Philadelphia

Nationwide Children’s Hospital

St. Louis Children’s Hospital

Seattle Children’s Hospital

Texas Children’s Hospital, Houston

St. Jude Children’s Research Hospital

Hospital for Sick Children, Toronto, Canada

Johns Hopkins Children’s Hospital, Baltimore, Maryland

University of Minnesota and Children’s Hospital and Clinics of Minnesota, Minneapolis, Minnesota

"PNOC is uniquely poised to make a significant difference in children with CNS malignancies, and has accomplished much in a short time. The collaborative nature of our group, the flexibility to develop trials based upon 'real-time' information, the freedom to conduct high-risk and high-reward studies, linking genomics to decisions, and samples to research strategies that we share among all interested parties, sets us apart."

- Michael Prados, MD