PNOC's highly ambitious, high reward research will change the course of pediatric brain cancer and save and improve children’s lives.

A check-up the family doctor or pediatrician.
Scientist in a laboratory


Through a ground-breaking global collaboration across 37 clinical sites around the globe, PNOC brings together 225+ researchers and clinicians dedicated to bringing new therapies to children and young adults with brain tumors. The intent is to be collaborative, forward thinking, strategic, and efficient in developing clinical trials for the highest unmet need patients. 


PNOC's disease specific research groups are accelerating progress. PNOC has dedicated research groups for: Low grade Glioma, Diffuse Midline Glioma/High grade Glioma (including DIPG), Medulloblastoma, Atypical Teratoid Rhabdoid Tumors (ATRT), Craniopharyngioma, Ependymoma, Germ Cell Tumors, Immunotherapy as well as Imaging, and DEI (Diversity, Equity, and Inclusion).


Traditional brain cancer protocols do not mandate tissue samples, and apply blanket treatments which can lead to ineffective treatments and serious adverse side effects. PNOC trials are based on precision medicine and immunotherapy, because we understand that each tumor is as unique as each child.


Many of PNOC's trials, if successful, will change the landscape for both children and adults. To date PNOC have opened 23 clinical trials, with several more set to open. Example of current trials:
• Using a modified measles virus to target one of pediatric brain cancer’s most aggressive and currently untreatable forms, AT/RT and recurrent medulloblastoma.
• The first ever testing of repeated injections of a nanoparticle embedded with a chemotherapy agent into the brainstem of children using flexible catheters.


Through PNOC's pioneering partnership with the Children’s Brain Tumor Network (CBTN), tissue samples and data are available in real time to researchers around the world. Through a suite of cloud-based data platforms CBTN has co-developed, researchers can access these rich collections of brain tumor data from anywhere in the world. 

PNOC has treated over 500 children with cutting edge treatments.

There are currently 23 active clinical trials underway.