Funding Cures. Saving Lives.
PNOC participating hospitals include:
There has never been a more hopeful time in history to invest in childhood cancer research.
Kids like Kyler deserve more than 499 days.
499 days will premiere at the Flyover Film festival in Louisville, KY at the Kentucky Science Center, on August 1, 2026
“By sharing Kyler's inspiring battle, we strive to raise awareness about the urgent need to support research, foster a compassionate community, drive meaningful change, and illuminate a path toward a future where every pediatric cancer fight is met with hope, a future where we lose no child.” — Jamie Buckner, 499 Days Director & Producer
499 Days is a feature length documentary that chronicles Kyler, a spirited boy from Louisville, KY, diagnosed with DIPG, a rare and aggressive brain cancer. The film features interviews with PNOC Co-founder Dr. Sabine Mueller, and PNOC Investigators Dr. Alyssa Reddy, Dr. Nalin Gupta and NP Carly Hoffman.
Join the 499 Days team in supporting PNOC Foundation’s Lose No Child campaign. Your support will create a future where we lose no child to brain cancer, where kids have safer, less toxic treatments and where more of them would get better, and fewer would suffer harsh, chronic side effects in and after remission.
Building on a decade of PNOC’s leadership and results, our goal is ambitious yet clear: to accelerate research and achieve in 5 years what typically takes a decade.
Why? Because these kids don’t have time.
Lose No Child is a bold and urgent $50 million campaign driving progress to transform treatment, advance research, and develop safer, more effective therapies for kids with brain cancer.
Collaboration, Speed and Hope
Kids with brain cancer don’t have time for business as usual. Neither do we.
“Every year, pediatric brain cancer steals almost 50,000 years of human life in the United States alone. Behind these statistics are countless young lives waiting, hoping, and fighting against a ticking clock. These kids don’t have time for business as usual.
There will be a day in the near future when I can say to families: This used to be an incurable disease, but through true collaboration we now have effective therapies”
Dr Sabine Mueller MD, PhD, MAS
Pediatric neurologist Pediatric
neuro-oncologist
UCSF, PNOC Consortium
Co-Founder & Project Lead
We Are Game-Changers
With a distinctive blend of speed and collaboration, we unite over 300 researchers across 43 leading institutions worldwide
to accelerate breakthroughs in pediatric
brain cancer.
We Fund Dream Teams
Our network brings together oncologists, neurologists, radiologists, biologists, surgeons, geneticists, data analysts, statisticians, patient families, and industry partners—all resolutely committed to eradicating pediatric brain cancer.
We’ve spent the last 10 years building a uniquely collaborative global clinical trial platform that gets results.
Fund our quest for breakthroughs, new and safer
treatments and cures today.
5000
Children are diagnosed
with brain cancer each year.
1%
Pediatric brain cancer
only receives 1% of
federal research funding.
#1
Pediatric brain cancer
is the leading cause of cancer
deaths amongst children.
Hope. Innovation. Action.
We are breaking barriers, transforming treatments, and giving children with brain cancer a future. But we can’t do it alone.
With your support, our doctors, researchers, and specialists can push the boundaries of what’s possible—faster, smarter, and with greater impact.
Join us. Be part of the cure.