Dr. Ashley Margol, MD, MS

PNOC Principal Investigator, Co-Project Leader

Dr. Ashley Margol is a pediatric neuro-oncologist and Director of the Brain Tumor Center at Children’s Hospital Los Angeles (CHLA) and Associate Professor of Clinical Pediatrics at the Keck School of Medicine of USC. Dr. Margol’s research is focused on embryonal tumors such as medulloblastoma and atypical teratoid rhabdoid tumor (ATRT) and integrating real-world evidence into clinical trial design.

Education

Education

  • BS, Zoology, University of Florida

  • MD, Keck School of Medicine, University of Southern California

  • MS, Clinical, Biomedical & Translational Research, University of Southern California

  • Internship, Pediatrics, LAC+USC Medical Center

  • Residency, Pediatrics, LAC+USC Medical Center

  • Chief Resident, Pediatrics, LAC+USC Medical Center

  • Fellowship, Pediatric Hematology/Oncology, Children’s Hospital Los Angeles

  • Advanced Training, Pediatric Neuro-Oncology, Children’s Hospital Los Angeles

Certifications

Certifications

  • American Board of Pediatrics, Pediatrics

  • American Board of Pediatrics, Subspecialty Certification in Pediatric Hematology/Oncology

Awards

Awards & Recognition

  • Walter Laug Distinguished Teacher Award for Outstanding Teaching, Guidance and Inspiration (2017)

  • Co-Chair, 2025 Society for Neuro-Oncology (SNO) Pediatric Neuro-Oncology Conference

  • Profiled by Children’s Hospital Los Angeles for PNOC real‑world evidence initiative (2024)

Research & Publications

Selected Research & Clinical Publications

  • Margol AS, Molinaro AM, Onar-Thomas A, Resnick A, Hanson D, Kieran M, et al. Use of external control cohorts in pediatric brain tumor clinical trials. J Clin Oncol. 2024 Apr 20;42(12):1340-1343. doi:10.1200/JCO.23.01084. Available from: https://pubmed.ncbi.nlm.nih.gov/38394473/

  • Margol AS, Hoffman LM, Ronsley R, Tran J, Malvar J, Chi YY, Leary S, Stevens J, Faulk KE, Salloum R, Hutchins SC, Wu C, Pillay-Smiley N, Aguilar A, Martinez M, Lafay-Cousin L, Abdelbaki MS, Cluster A, Perreault S, Gilheeney S, Szalontay L, Reddy A, Dhall G. A multi-institutional report of children with atypical teratoid rhabdoid tumor treated with intensive multimodal therapy. Neuro-Onc Pract. https://doi.org/10.1093/nop/npag014. February 2026. 

  • Margol AS, Robison NJ, Gnanachandran J, Hung LT, Kennedy RJ, Vali M, Dhall G, Finlay JL, Erdreich-Epstein A, Krieger MD, Drissi R, Fouladi M, Gilles FH, Judkins AR, Sposto R and Asgharzadeh S.  Tumor-associated macrophages in SHH subgroup of medulloblastomas.  Clin Cancer Res. 2015 Mar 15;21(6):1457-65. doi: 10.1158/1078-0432.CCR-14-1144. Epub 2014 Oct 24Available from:  https://pubmed.ncbi.nlm.nih.gov/25344580/

For a complete list of published work:

https://www.ncbi.nlm.nih.gov/myncbi/ashley.margol.1/bibliography/public/