Clinical Cancer Research Measles Oncolytic Virus as an Immunotherapy for Recurrent/Refractory Pediatric Medulloblastoma and Atypical Teratoid/Rhabdoid Tumor: Results from PNOC005, August, 2025

Neuro-Oncology Rational combination platform trial design for children and young adults with diffuse midline glioma: A report from PNOC, April, 2024

Journal of Clinical Investigations Just a spoonful of metformin helps the medicine go down, March, 2024

Journal of Clinical Oncology PNOC001: Phase II Study of Everolimus For Recurrent or Progressive Low-Grade Gliomas in Children, November, 2023

Pediatric Neurosurgery Advances and Clinical Trials Update in the Treatment of Diffuse Intrinsic Pontine Gliomas, November, 2023

American Association for Cancer Research Journal ONC201 in Combination with Paxalisib for the Treatment of H3K27-Altered Diffuse Midline Glioma, July, 2023

Neoplasia Journal Machine Learning Identifies Subgroups of Pediatric Low-grade Gliomas that Correlate with Key Molecular Markers, February, 2023

Neoplasia Journal Interdisciplinary care of children with diffuse midline glioma, January, 2023

European Journal of Cancer Real-time drug testing of paediatric diffuse midline glioma to support clinical decision making: The Zurich DIPG/DMG centre experience, January, 2023

Clinical Cancer Research Upfront Biology-Guided Therapy in Diffuse Intrinsic Pontine Glioma: Therapeutic, Molecular, and Biomarker Outcomes from PNOC003, September, 2022

Neuro-Oncology DIPG-31. Prognostic and predictive biomarkers of response in children and young adults with H3K27M-altered diffuse intrinsic pontine glioma: results from a multi-center, interventional clinical trial (PNOC003), June, 2022

Journal of Neurosurgery Liquid biopsy for diffuse intrinsic pontine glioma: an update, September, 2019

International Journal of Cancer A pilot precision medicine trial for children with diffuse intrinsic pontine glioma-PNOC003: A report from the Pacific Pediatric Neuro-Oncology Consortium, April, 2019

Neuro-Oncology DIPG-76. PNOC-003: PRECISION MEDICINE TRIAL FOR CHILDREN WITH DIFFUSES INTRINSIC PONTINE GLIOMA: PRELIMINARY EXPERIENCE WITH MULTI-AGENT PERSONALIZED THERAPY RECOMMENDATIONS, June, 2018

PNOC participating sites include: Ann & Robert H. Lurie Children’s Hospital of Chicago CHICAGO, IL Children’s Cancer Hospital, Egypt CAIRO, EGYPT Children’s Hospital Los Angeles LOS ANGELES, CA Children’s Minnesota MINNEAPOLIS, MN Children’s National Hospital WASHINGTON, DC Dana-Farber/Boston Children’s Cancer and Blood Disorders Center BOSTON, MA Doernbecher Children’s Hospital Oregon Health & Science University (OHSU) PORTLAND, OR Duke University Medical Center DURHAM, NC John Hunter Hospital NEWCASTLE, AUSTRALIA Johns Hopkins Hospital BALTIMORE, MD Joseph M. Sanzari Children’s Hospital at Hackensack University Medical Center HACKENSACK, NJ Monash Children’s Hospital CLAYTON, AUSTRALIA Nationwide Children’s Hospital COLUMBUS, OH, NYU Langone Health NEW YORK CITY, NY Perth Children’s Hospital PERTH, AUSTRALIA Princess Maxima Center UTRECHT, THE NETHERLANDS Queensland Children’s Hospital BRISBANE, AUSTRALIA Riley Hospital for Children at Indiana University Health INDIANAPOLIS, IN Royal Children’s Hospital Melbourne MELBOURNE, AUSTRALIA Sao Paulo Children’s Hospital SAO PAULO, BRAZIL, St. Jude Children’s Research Hospital MEMPHIS, TN St. Louis Children’s Hospital ST. LOUIS, MO Seattle Children’s Hospital SEATTLE, WA Shaare Zedek Medical Center JERUSALEM, ISRAEL Sydney Children’s Hospital SYDNEY, AUSTRALIA Sheba Medical Center RAMAT GAN, ISRAEL Starship Children’s Hospital AUCKLAND, NEW ZEALAND Tata Memorial Centre, Mumbai MUMBAI, INDIA The Children’s Hospital of Philadelphia PHILADELPHIA, The Children’s Hospital at Westmead WESTMEAD, AUSTRALIA University Children’s Hospital Zürich ZURICH, SWITZERLAND University of Alabama at Birmingham, Children’s of Alabama BIRMINGHAM, ALABAMA University of California, San Diego Rady Children’s Hospital SAN DIEGO, CA UCSF Benioff Children’s Hospitals SAN FRANCISCO, CA University of Michigan – C.S. Mott Children’s Hospital ANN ARBOR, MI University of Florida Shands Children’s Hospital GAINESVILLE, FL University of Utah SALT LAKE CITY, UT Women’s and Children’s Hospital ADELAIDE, AUSTRALIA Children’s Hospital of Michigan DETROIT, MI Huntsman Cancer Center SALT LAKE CITY,​​ UTAH Texas Children’s Hospital HOUSTON, TEXAS University of California, Los Angeles LOS ANGELES, CA Yale University, Yale Cancer Center NEW HAVEN, CT.

For information on current PNOC clinical trials click here. To find out if your child is eligible to enroll in a PNOC clinical trial, contact the closest participating site or contact us the PNOC Operations team info@pnoc.us.